Asian markets mostly fell Tuesday as investors took a breather after the previous day's rally, with the mood dampened by news that a vaccine trial had been halted after a volunteer fell ill.
While Wall Street provided a strong lead thanks to a surge in tech stocks, regional traders struggled to take up the baton with sentiment continuing to be kept in check by spiking virus infections and the reimposition of some lockdowns around the world.
There was little movement after remarks by a top Democrat who said the House should not expect any action on a new stimulus this week, making a rescue deal even more unlikely before the November 3 election. Republicans for their part have rejected the $1.8 trillion offer put forward by the White House last week.
Still there is a broad expectation that a bill will eventually be passed at some point — and with Joe Biden well ahead in polls while Democrats could win both arms of Congress, talk is of a bigger package.
Analysts said the prospect of a big cash injection into the struggling economy was trumping worries about a possibly less-pro-business Biden, whose huge poll leads are also easing worries about a drawn-out result.
"For now it seems the reduced uncertainty over the election and the promise of large-scale fiscal stimulus is evidently overriding concerns about higher corporate taxes and more regulation. 'We can worry about that later, if ever' seems to be the current investor market mindset," said National Australia Bank's Ray Attrill.
But for now, worries about the development of a vaccine are playing on investors' minds after Johnson & Johnson said it had temporarily halted its trial after a participant fell sick.
The firm said serious adverse events were "an expected part of any clinical study, especially large studies", adding company guidelines allowed officials to pause a study to determine if the problem was related to the drug in question and whether to resume the study.
The news dealt a blow to hopes for an effective treatment for the disease, which as killed more than a million people, infected tens of millions and plunged the global economy into recession.
Tokyo, Shanghai, Seoul, Taipei, Manila and Jakarta were all in the red though Sydney, Singapore and Wellington enjoyed gains. Hong Kong was closed because of a typhoon.
Key figures around 0230 GMT
Tokyo – Nikkei 225: DOWN 0.1 percent at 23,525.95 (break)
Hong Kong – Hang Seng: Morning trade cancelled
Shanghai – Composite: DOWN 0.6 percent at 3,339.44
Euro/dollar: DOWN at $1.1793 from $1.1809 at 2130 GMT
Pound/dollar: DOWN at $1.3040 from $1.3066
Dollar/yen: UP at 105.37 yen from 105.32 yen
Euro/pound: UP at 90.44 pence from 90.35 pence
West Texas Intermediate: UP 0.1 percent at $39.45 per barrel
Brent North Sea crude: UP 0.1 percent at $41.75 per barrel
New York – Dow Jones: UP 0.9 percent to 28,837.52 (close)
London – FTSE 100: DOWN 0.3 percent at 6,001.38 (close)